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Year : 2023  |  Volume : 2  |  Issue : 1  |  Page : 21-24

Perspectives on rehabilitation, exercise and synaptogenesis after stroke

1 Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA
2 China-America Institute of Neuroscience, Beijing Luhe Hospital, Capital Medical University, Beijing, China

Correspondence Address:
Yuchuan Ding
Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2773-2398.372308

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Strokes are a leading cause of death, persistent neurological deficits, and physical disability worldwide. Exercise-mediated adaptations are an emerging form of therapies that aim to attenuate the severity of post-stroke physical disability; however, there are uncertainties regarding how specific parameters, such as time to initiation and intensity of exercise, affect rehabilitation outcomes. At the cellular level, physical rehabilitation after stroke may enhance post-stroke gluconeogenesis to promote neuroplasticity over cellular damage via hypoxia-inducible factor-1α and exosomes. Furthermore, there is thought to be an optimal time for the initiation of exercise after a stroke, but there is disagreement and uncertainty about this optimal time. This paper discusses the pathophysiology of physical rehabilitation after stroke and reviews current studies on the effects of physical exercise on stroke rehabilitation and plasticity.

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