• Users Online: 159
  • Print this page
  • Email this page
RESEARCH ARTICLE
Year : 2022  |  Volume : 1  |  Issue : 4  |  Page : 173-178

Blood analysis by Raman spectroscopy for laser stimulation on mouse prefrontal cortex


1 Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China
2 School of Electron and Computer, Southeast University Chengxian College, Nanjing, Jiangsu Province, China
3 Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Correspondence Address:
Shu-Peng Liu
Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2773-2398.365027

Rights and Permissions

Low-level laser therapy, a noninvasive physical therapy, is applied to a wide range of conditions and has many effects including anti-inflammatory, analgesic, and anti-allergic effects. Some reports show that low-level laser therapy improves memory for patients. In this study, we explored the effect of laser stimulation on the prefrontal cortex of Alzheimer’s disease model mice. Ten 4-month-old APP/PS1 double-transgenic Alzheimer’s disease model mice were selected for prefrontal cortex stimulation by an 808-nm laser for 40 minutes every day. The peak intensities of blood Raman spectroscopy at 675, 747, 1124 (P < 0.05), 1223 (P < 0.05), 1305, 1340, 1372, 1540, and 1637 cm-1 were different between the laser stimulation group and the control group. The results indicated that laser stimulation of the mouse prefrontal cortex may induce some changes in blood components, such as porphyrins and glucose. Laser stimulation could play a role in the neurophysiological activity, thereby triggering the changes in blood components that could be detected by Raman spectroscopy.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed200    
    Printed14    
    Emailed0    
    PDF Downloaded26    
    Comments [Add]    

Recommend this journal