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REVIEW
Year : 2022  |  Volume : 1  |  Issue : 3  |  Page : 122-127

Biomaterials as regenerative therapies for traumatic brain injury: a narrative review


1 Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Institute of Rehabilitation Medicine, School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2 School of Kinesiology, Shanghai University of Sport, Shanghai, China
3 School of Life Science and Technology, Shanghai Tech University, Shanghai, China

Correspondence Address:
Wang Hui
Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Institute of Rehabilitation Medicine, School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2773-2398.356521

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Over recent years, the events associated with traumatic brain injury (TBI) have become critical health problems. TBI involves various functional deficits that are caused by neuronal loss and is a common feature in various neuropathologies. Patients with TBI have a very high degree of disability and impairment at both the physical and psychological levels, thus creating a significant burden on the quality of life. Although stem cell therapy has achieved some success in the reconstruction of neural circuits for TBI therapies, there are several limitations that need to be overcome, such as the stem cell transplantation pathways and time to transplantation are challenges for clinical application. Recently, bioactive materials from the tissue engineering field have become promising candidates for TBI therapies. Herein, we briefly summarize and discuss the advantages and disadvantages of TBI-related biomaterials (such as hydrogels, nanofibers, and nanomaterials) for the regeneration of neural tissue and functional recovery at the lesion sites of TBI. Finally, we describe the desirable characteristics of bioactive materials for neural repair in TBI. Because the development of therapeutic strategies with biomaterials is still in its infancy, biomaterials deserve high priority and further development as a treatment for TBI.


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